{
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  "Title": "Multi-Trait Analysis of Rare-Variant Association Study",
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  "Authors@R": "c(person(\"Lan\", \"Luo\", role = c(\"aut\", \"cre\"), email =\n\"lanluoruc@gmail.com\"))",
  "Maintainer": "Lan Luo <lanluoruc@gmail.com>",
  "Description": "Perform multi-trait rare-variant association tests using\nthe summary statistics and adjust for possible sample overlap.\nPackage is based on \"Multi-Trait Analysis of Rare-Variant\nAssociation Summary Statistics using MTAR\" by Luo, L., Shen,\nJ., Zhang, H., Chhibber, A. Mehrotra, D.V., Tang, Z., 2019\n(submitted).",
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    "Date": "2026-10-17 07:33:15 UTC",
    "User": "root"
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  "Author": "Lan Luo [aut, cre]",
  "Repository": "https://lan.r-universe.dev",
  "Date/Publication": "2020-04-22 19:44:10 UTC",
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    "description": "",
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  "_assets": [
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    "extra/citation.json",
    "extra/citation.txt",
    "extra/contents.json",
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      "date": "2020-03-01"
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      "class": [
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      ],
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      "tojson": true
    },
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      "class": [
        "list"
      ],
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      "table": false,
      "tojson": true
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      "title": "Example1: individual-level data",
      "object": "rawdata",
      "class": [
        "list"
      ],
      "fields": [],
      "table": true,
      "tojson": true
    },
    {
      "name": "varU.example",
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      "object": "varU.example",
      "class": [
        "list"
      ],
      "fields": [],
      "table": false,
      "tojson": true
    },
    {
      "name": "zeta.example",
      "title": "Example4: the summary statistics of 737 common and null SNPs",
      "object": "zeta.example",
      "class": [
        "list"
      ],
      "fields": [],
      "table": true,
      "tojson": true
    }
  ],
  "_help": [
    {
      "page": "beta.example",
      "title": "Example3: the genetic effect estimates and their standard errors",
      "topics": [
        "beta.example"
      ]
    },
    {
      "page": "Get_UV_from_beta",
      "title": "Compute the summary statistics given the genetic effect estimates and their standard errors",
      "topics": [
        "Get_UV_from_beta"
      ]
    },
    {
      "page": "Get_UV_from_data",
      "title": "Compute the summary statistics given the individual-level data",
      "topics": [
        "Get_UV_from_data"
      ]
    },
    {
      "page": "Get_UV_from_varU",
      "title": "Compute the summary statistics given the score statistics and their variance.",
      "topics": [
        "Get_UV_from_varU"
      ]
    },
    {
      "page": "Get_zeta",
      "title": "Calculate Covariances of Z-scores between Traits from Overlapping Samples",
      "topics": [
        "Get_zeta"
      ]
    },
    {
      "page": "MTAR",
      "title": "Multiple-Traits Analysis of Rare-Variant Association Test",
      "topics": [
        "MTAR"
      ]
    },
    {
      "page": "MTAR.example",
      "title": "PNPLA2 Gene",
      "topics": [
        "MTAR.example"
      ]
    },
    {
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      "title": "Example1: individual-level data",
      "topics": [
        "rawdata"
      ]
    },
    {
      "page": "varU.example",
      "title": "Example2: the summary statistics and their variance",
      "topics": [
        "varU.example"
      ]
    },
    {
      "page": "zeta.example",
      "title": "Example4: the summary statistics of 737 common and null SNPs",
      "topics": [
        "zeta.example"
      ]
    }
  ],
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    "lattice",
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      "filename": "MTAR.html",
      "title": "Multi-trait analysis of rare-variant association summary statistics using MTAR",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Contents",
        "Overview",
        "System Requirements",
        "Installing Guide",
        "Package dependencies",
        "Demo",
        "Step 1: Prepare Summary Statistics for Multiple Traits",
        "1. Given the Individual-Level Data",
        "2. Given Score Statistics and their Variance",
        "3. Given Genetic Effect Estimates and their Standard Errors",
        "Step 2. Calculate Covariances of Z-scores between Traits from Overlapping Samples",
        "Step 3. Run Multi-Traits Rare-Variant Association Tests (MTAR)",
        "URLs",
        "References"
      ],
      "created": "2020-04-22 19:44:10",
      "modified": "2020-04-22 19:44:10",
      "commits": 1
    }
  ],
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  "_indexed": true,
  "_nocasepkg": "mtar",
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